Drug interactions
Hydroxyurea + Temozolomide
Severity: Moderate
Hydroxyurea and Temozolomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress the bone marrow, and temozolomide can cause delayed thrombocytopenia and neutropenia. The combination may deepen cytopenias and raise the risk of infection and bleeding.
What this interaction means in plain words
Hydroxyurea and Temozolomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyurea belongs to Miscellaneous; Temozolomide belongs to Oncology.
Why it happens
Additive myelosuppression from an alkylating agent and an antimetabolite.
What to do
Monitor complete blood counts regularly, including nadir values. Reduce doses or delay cycles if counts do not recover.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temozolomide
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Hydroxyurea with Temozolomide?
MediHelp rates the interaction as moderate. Hydroxyurea and Temozolomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress the bone marrow, and temozolomide can cause delayed thrombocytopenia and neutropenia. The combination may deepen cytopenias and raise the risk of infection and bleeding.
How serious is the interaction between Hydroxyurea and Temozolomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly, including nadir values. Reduce doses or delay cycles if counts do not recover.
What other medicines interact with Temozolomide?
MediHelp also lists interactions of Temozolomide with, for example, Adenovirus types 4 and 7 live, Belatacept, Deferiprone. The full list is on the Temozolomide page.
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