Drug interactions
Hydroxyzine + Ibutilide
Severity: Major
Hydroxyzine and Ibutilide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide markedly prolongs the QT interval and can cause torsades de pointes soon after infusion. Hydroxyzine adds to the risk.
What this interaction means in plain words
Hydroxyzine and Ibutilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxyzine belongs to Respiratory; Ibutilide belongs to Cardiovascular.
Why it happens
Additive QTc prolongation through blockade of cardiac potassium currents.
What to do
Avoid hydroxyzine around ibutilide administration. Use continuous ECG monitoring and keep potassium and magnesium normal if ibutilide is given.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Hydroxyzine with Ibutilide?
MediHelp rates the interaction as major. Hydroxyzine and Ibutilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibutilide markedly prolongs the QT interval and can cause torsades de pointes soon after infusion. Hydroxyzine adds to the risk.
How serious is the interaction between Hydroxyzine and Ibutilide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid hydroxyzine around ibutilide administration. Use continuous ECG monitoring and keep potassium and magnesium normal if ibutilide is given.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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