Drug interactions
Hydroxyzine + Isoproterenol
Severity: Minor
Hydroxyzine and Isoproterenol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine can prolong the QT interval and cause arrhythmia, while isoproterenol causes tachycardia and hypokalemia that may promote proarrhythmia. Together, the risk of ventricular arrhythmia may be modestly increased in susceptible patients.
What this interaction means in plain words
Hydroxyzine and Isoproterenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydroxyzine belongs to Respiratory; Isoproterenol belongs to Respiratory.
Why it happens
Additive proarrhythmic potential: hydroxyzine prolongs QT and beta-agonist-induced hypokalemia and tachycardia add risk.
What to do
Monitor ECG and serum potassium in patients with QT risk factors receiving both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoproterenol
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Isoproterenol?
MediHelp rates the interaction as minor. Hydroxyzine and Isoproterenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyzine can prolong the QT interval and cause arrhythmia, while isoproterenol causes tachycardia and hypokalemia that may promote proarrhythmia. Together, the risk of ventricular arrhythmia may be modestly increased in susceptible patients.
How serious is the interaction between Hydroxyzine and Isoproterenol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium in patients with QT risk factors receiving both drugs.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
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