Drug interactions
Hydroxyzine + Lemborexant
Severity: Moderate
Hydroxyzine and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so taking them together can deepen drowsiness and impair alertness, coordination and next-day psychomotor performance. The risk is greatest in older adults and at higher doses.
What this interaction means in plain words
Hydroxyzine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Lemborexant belongs to Central Nervous System.
Why it happens
Additive central nervous system depression from H1 antagonism (hydroxyzine) and orexin receptor antagonism (lemborexant).
What to do
Use the lowest effective dose of each drug and counsel patients about next-day impairment and driving. Reassess the need for lemborexant dose reduction if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Hydroxyzine with Lemborexant?
MediHelp rates the interaction as moderate. Hydroxyzine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so taking them together can deepen drowsiness and impair alertness, coordination and next-day psychomotor performance. The risk is greatest in older adults and at higher doses.
How serious is the interaction between Hydroxyzine and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of each drug and counsel patients about next-day impairment and driving. Reassess the need for lemborexant dose reduction if excessive sedation occurs.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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