Drug interactions
Hydroxyzine + Loxapine
Severity: Moderate
Hydroxyzine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine with anticholinergic effects and a recognized association with QT prolongation. With loxapine it can cause excessive sedation, anticholinergic toxicity and an additive risk of QT-related arrhythmia.
What this interaction means in plain words
Hydroxyzine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects, with additive potential for QT prolongation.
What to do
Use the lowest effective doses and warn about sedation. Consider an ECG and electrolyte check in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Loxapine?
MediHelp rates the interaction as moderate. Hydroxyzine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is a sedating antihistamine with anticholinergic effects and a recognized association with QT prolongation. With loxapine it can cause excessive sedation, anticholinergic toxicity and an additive risk of QT-related arrhythmia.
How serious is the interaction between Hydroxyzine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn about sedation. Consider an ECG and electrolyte check in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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