Drug interactions
Hydroxyzine + Memantine-donepezil
Severity: Moderate
Hydroxyzine and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine can prolong the QT interval and donepezil may add to this effect. Hydroxyzine is also strongly anticholinergic, which can counteract donepezil and worsen confusion in older patients.
What this interaction means in plain words
Hydroxyzine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus pharmacodynamic antagonism by antimuscarinic activity.
What to do
Avoid hydroxyzine in patients with dementia where possible and choose a non-sedating, non-anticholinergic alternative. If used, monitor the ECG and cognition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Memantine-donepezil?
MediHelp rates the interaction as moderate. Hydroxyzine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine can prolong the QT interval and donepezil may add to this effect. Hydroxyzine is also strongly anticholinergic, which can counteract donepezil and worsen confusion in older patients.
How serious is the interaction between Hydroxyzine and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid hydroxyzine in patients with dementia where possible and choose a non-sedating, non-anticholinergic alternative. If used, monitor the ECG and cognition.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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