Drug interactions
Hydroxyzine + Methocarbamol
Severity: Moderate
Hydroxyzine and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine with anxiolytic effects. With methocarbamol it can cause additive drowsiness, dizziness and impaired psychomotor performance.
What this interaction means in plain words
Hydroxyzine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from a sedating antihistamine and a centrally acting muscle relaxant.
What to do
Monitor for oversedation and counsel against driving or operating machinery. Use the lowest effective doses, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Methocarbamol?
MediHelp rates the interaction as moderate. Hydroxyzine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is a sedating antihistamine with anxiolytic effects. With methocarbamol it can cause additive drowsiness, dizziness and impaired psychomotor performance.
How serious is the interaction between Hydroxyzine and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and counsel against driving or operating machinery. Use the lowest effective doses, especially in older adults.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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