Drug interactions
Hydroxyzine + Methohexital
Severity: Moderate
Hydroxyzine and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic, and hydroxyzine has sedative antihistamine effects, so together they can deepen sedation and cause respiratory and cardiovascular depression. This is used deliberately in procedural premedication but needs a controlled setting.
What this interaction means in plain words
Hydroxyzine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation (methohexital) and central H1 antagonism (hydroxyzine).
What to do
Reduce the methohexital dose as needed and titrate to effect, with continuous monitoring of oxygen saturation, respiration and blood pressure. Ensure airway equipment and trained personnel are available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydroxyzine and Methohexital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Methohexital
Frequently asked questions
Can I take Hydroxyzine with Methohexital?
MediHelp rates the interaction as moderate. Hydroxyzine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate anesthetic, and hydroxyzine has sedative antihistamine effects, so together they can deepen sedation and cause respiratory and cardiovascular depression. This is used deliberately in procedural premedication but needs a controlled setting.
How serious is the interaction between Hydroxyzine and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the methohexital dose as needed and titrate to effect, with continuous monitoring of oxygen saturation, respiration and blood pressure. Ensure airway equipment and trained personnel are available.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
