Drug interactions
Hydroxyzine + Primaquine
Severity: Moderate
Hydroxyzine and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine can prolong the QT interval, and primaquine may add to this effect. Together they may increase the risk of torsades de pointes, particularly in older patients or those with cardiac disease.
What this interaction means in plain words
Hydroxyzine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Primaquine belongs to Anti Parasitic.
Why it happens
Additive QTc prolongation.
What to do
Check a baseline ECG and electrolytes, and use the lowest effective hydroxyzine dose. Choose a non-QT-prolonging alternative in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Primaquine?
MediHelp rates the interaction as moderate. Hydroxyzine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine can prolong the QT interval, and primaquine may add to this effect. Together they may increase the risk of torsades de pointes, particularly in older patients or those with cardiac disease.
How serious is the interaction between Hydroxyzine and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and use the lowest effective hydroxyzine dose. Choose a non-QT-prolonging alternative in high-risk patients.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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