Drug interactions
Hydroxyzine + Rimabotulinumtoxinb
Severity: Moderate
Hydroxyzine and Rimabotulinumtoxinb: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine has anticholinergic activity that could add to the effects of botulinum toxin. This might increase neuromuscular weakness or systemic anticholinergic symptoms, though clinical reports are limited.
What this interaction means in plain words
Hydroxyzine and Rimabotulinumtoxinb can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Rimabotulinumtoxinb belongs to Musculoskeletal.
Why it happens
Additive anticholinergic pharmacodynamic effects may potentiate the neuromuscular blockade produced by botulinum toxin.
What to do
Monitor for excessive muscle weakness, swallowing or breathing difficulty, and anticholinergic effects after injection. Consider an alternative to hydroxyzine if such symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Rimabotulinumtoxinb
- Amikacin + Rimabotulinumtoxinb Moderate
- Amitriptyline + Rimabotulinumtoxinb Moderate
- Atracurium + Rimabotulinumtoxinb Moderate
- Atropine + Rimabotulinumtoxinb Moderate
- Baclofen + Rimabotulinumtoxinb Moderate
- Benztropine + Rimabotulinumtoxinb Moderate
Frequently asked questions
Can I take Hydroxyzine with Rimabotulinumtoxinb?
MediHelp rates the interaction as moderate. Hydroxyzine and Rimabotulinumtoxinb can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine has anticholinergic activity that could add to the effects of botulinum toxin. This might increase neuromuscular weakness or systemic anticholinergic symptoms, though clinical reports are limited.
How serious is the interaction between Hydroxyzine and Rimabotulinumtoxinb?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive muscle weakness, swallowing or breathing difficulty, and anticholinergic effects after injection. Consider an alternative to hydroxyzine if such symptoms develop.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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