Drug interactions
Hydroxyzine + Sertraline
Severity: Moderate
Hydroxyzine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydroxyzine and sertraline can prolong the QT interval. Combined use increases the risk of ventricular arrhythmia, particularly in older patients or those with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Hydroxyzine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Sertraline belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Use the lowest effective hydroxyzine dose for the shortest time and avoid in patients with other QT risk factors. Check ECG and electrolytes where risk is elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Sertraline?
MediHelp rates the interaction as moderate. Hydroxyzine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both hydroxyzine and sertraline can prolong the QT interval. Combined use increases the risk of ventricular arrhythmia, particularly in older patients or those with cardiac disease or electrolyte disturbances.
How serious is the interaction between Hydroxyzine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydroxyzine dose for the shortest time and avoid in patients with other QT risk factors. Check ECG and electrolytes where risk is elevated.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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