Drug interactions
Hydroxyzine + Tranylcypromine
Severity: Moderate
Hydroxyzine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can intensify and prolong the anticholinergic and sedative effects of hydroxyzine. This may cause marked drowsiness, dry mouth, urinary retention and confusion.
What this interaction means in plain words
Hydroxyzine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Use the lowest effective hydroxyzine dose and monitor for sedation and anticholinergic effects. Consider a non-sedating alternative for allergy or a non-anticholinergic option for anxiety.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Tranylcypromine?
MediHelp rates the interaction as moderate. Hydroxyzine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can intensify and prolong the anticholinergic and sedative effects of hydroxyzine. This may cause marked drowsiness, dry mouth, urinary retention and confusion.
How serious is the interaction between Hydroxyzine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydroxyzine dose and monitor for sedation and anticholinergic effects. Consider a non-sedating alternative for allergy or a non-anticholinergic option for anxiety.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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