Drug interactions
Hydroxyzine + Vardenafil
Severity: Moderate
Hydroxyzine and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is associated with QT prolongation and torsades de pointes, and vardenafil adds a small QT effect. The combination may raise arrhythmia risk, especially in older patients or those with electrolyte disturbances.
What this interaction means in plain words
Hydroxyzine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Vardenafil belongs to Genitourinary.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Use the lowest effective hydroxyzine dose for the shortest time and correct electrolyte abnormalities. Obtain an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Vardenafil?
MediHelp rates the interaction as moderate. Hydroxyzine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is associated with QT prolongation and torsades de pointes, and vardenafil adds a small QT effect. The combination may raise arrhythmia risk, especially in older patients or those with electrolyte disturbances.
How serious is the interaction between Hydroxyzine and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydroxyzine dose for the shortest time and correct electrolyte abnormalities. Obtain an ECG in patients with other QT risk factors.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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