Drug interactions
Hyoscyamine + Imipramine
Severity: Moderate
Hyoscyamine and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine has substantial antimuscarinic activity, and hyoscyamine adds to it. Together they can cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, especially in older patients. Risk of paralytic ileus and acute angle-closure glaucoma is increased in susceptible people.
What this interaction means in plain words
Hyoscyamine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hyoscyamine belongs to Genitourinary; Imipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic (anticholinergic) pharmacodynamic effects.
What to do
Monitor for anticholinergic toxicity such as urinary retention, constipation, and confusion, and reduce the dose or choose a non-anticholinergic alternative if symptoms appear. Take extra care in older adults and those with glaucoma or prostatic hypertrophy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Imipramine?
MediHelp rates the interaction as moderate. Hyoscyamine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine has substantial antimuscarinic activity, and hyoscyamine adds to it. Together they can cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, especially in older patients. Risk of paralytic ileus and acute angle-closure glaucoma is increased in susceptible people.
How serious is the interaction between Hyoscyamine and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as urinary retention, constipation, and confusion, and reduce the dose or choose a non-anticholinergic alternative if symptoms appear. Take extra care in older adults and those with glaucoma or prostatic hypertrophy.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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