Drug interactions
Hyoscyamine + Rocuronium
Severity: Minor
Hyoscyamine and Rocuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is an antimuscarinic with no important effect on nicotinic neuromuscular blockade. Additive anticholinergic effects such as tachycardia are possible.
What this interaction means in plain words
Hyoscyamine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hyoscyamine belongs to Genitourinary; Rocuronium belongs to Musculoskeletal.
Why it happens
Muscarinic blockade with negligible nicotinic receptor activity.
What to do
No adjustment is needed; monitor heart rate and neuromuscular recovery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rocuronium
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Rocuronium?
MediHelp rates the interaction as minor. Hyoscyamine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hyoscyamine is an antimuscarinic with no important effect on nicotinic neuromuscular blockade. Additive anticholinergic effects such as tachycardia are possible.
How serious is the interaction between Hyoscyamine and Rocuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor heart rate and neuromuscular recovery.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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