Drug interactions
Hyoscyamine spray + Prochlorperazine
Severity: Moderate
Hyoscyamine spray and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine given as an oral spray is absorbed systemically and adds to the anticholinergic effects of prochlorperazine. Dry mouth, constipation, urinary retention, blurred vision and confusion may be intensified.
What this interaction means in plain words
Hyoscyamine spray and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects through pharmacodynamic synergism.
What to do
Monitor for anticholinergic adverse effects, particularly in older patients. Reduce the dose or stop one agent if significant symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Hyoscyamine spray with Prochlorperazine?
MediHelp rates the interaction as moderate. Hyoscyamine spray and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine given as an oral spray is absorbed systemically and adds to the anticholinergic effects of prochlorperazine. Dry mouth, constipation, urinary retention, blurred vision and confusion may be intensified.
How serious is the interaction between Hyoscyamine spray and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, particularly in older patients. Reduce the dose or stop one agent if significant symptoms appear.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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