Drug interactions
Hyoscyamine spray + Umeclidinium
Severity: Moderate
Hyoscyamine spray and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine oral spray is absorbed systemically and adds antimuscarinic effects to inhaled umeclidinium. Dry mouth, constipation, urinary retention and tachycardia may be increased.
What this interaction means in plain words
Hyoscyamine spray and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid combining where an alternative exists. Monitor for urinary retention, constipation and cognitive effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
Frequently asked questions
Can I take Hyoscyamine spray with Umeclidinium?
MediHelp rates the interaction as moderate. Hyoscyamine spray and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine oral spray is absorbed systemically and adds antimuscarinic effects to inhaled umeclidinium. Dry mouth, constipation, urinary retention and tachycardia may be increased.
How serious is the interaction between Hyoscyamine spray and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where an alternative exists. Monitor for urinary retention, constipation and cognitive effects.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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