Drug interactions
Ibrutinib + Vortioxetine
Severity: Moderate
Ibrutinib and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and is associated with bleeding, while vortioxetine can also affect platelet serotonin uptake. Combined use may further increase the risk of hemorrhage.
What this interaction means in plain words
Ibrutinib and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive effects on platelet function through BTK inhibition and reduced platelet serotonin uptake.
What to do
Monitor for bruising and bleeding, and review concurrent anticoagulants or antiplatelets. Hold ibrutinib around surgery according to labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Vortioxetine?
MediHelp rates the interaction as moderate. Ibrutinib and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and is associated with bleeding, while vortioxetine can also affect platelet serotonin uptake. Combined use may further increase the risk of hemorrhage.
How serious is the interaction between Ibrutinib and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising and bleeding, and review concurrent anticoagulants or antiplatelets. Hold ibrutinib around surgery according to labeling.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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