Drug interactions
Ibuprofen + Lacosamide
Severity: Minor
Ibuprofen and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lacosamide is partly metabolized by CYP2C9, CYP2C19 and CYP3A4, and ibuprofen is only a weak CYP2C9 substrate and competitor. No meaningful rise in lacosamide exposure is expected in practice.
What this interaction means in plain words
Ibuprofen and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Lacosamide belongs to Central Nervous System.
Why it happens
Theoretical competition for CYP2C9 metabolism, which is of negligible clinical significance.
What to do
No dose adjustment of lacosamide is needed. Be aware of dizziness or other adverse effects if symptoms emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Ibuprofen with Lacosamide?
MediHelp rates the interaction as minor. Ibuprofen and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lacosamide is partly metabolized by CYP2C9, CYP2C19 and CYP3A4, and ibuprofen is only a weak CYP2C9 substrate and competitor. No meaningful rise in lacosamide exposure is expected in practice.
How serious is the interaction between Ibuprofen and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment of lacosamide is needed. Be aware of dizziness or other adverse effects if symptoms emerge.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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