Drug interactions
Ibuprofen + Levoketoconazole
Severity: Minor
Ibuprofen and Levoketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a CYP inhibitor, though it mainly affects CYP3A4, with weaker CYP2C9 inhibition possible. Ibuprofen exposure may rise slightly, with limited clinical significance expected.
What this interaction means in plain words
Ibuprofen and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Levoketoconazole belongs to Endocrine.
Why it happens
Possible inhibition of CYP2C9-mediated ibuprofen metabolism.
What to do
No routine adjustment is needed; use the lowest effective ibuprofen dose, and monitor for GI and renal effects with prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Ibuprofen with Levoketoconazole?
MediHelp rates the interaction as minor. Ibuprofen and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levoketoconazole is a CYP inhibitor, though it mainly affects CYP3A4, with weaker CYP2C9 inhibition possible. Ibuprofen exposure may rise slightly, with limited clinical significance expected.
How serious is the interaction between Ibuprofen and Levoketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; use the lowest effective ibuprofen dose, and monitor for GI and renal effects with prolonged use.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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