Drug interactions
Ibuprofen + Paromomycin
Severity: Minor
Ibuprofen and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed, so systemic interactions are unlikely in most patients. The reported effect is in preterm infants given ibuprofen, in whom reduced renal clearance increases aminoglycoside levels.
What this interaction means in plain words
Ibuprofen and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Paromomycin belongs to Anti Bacterial.
Why it happens
NSAID-related reduction in renal clearance may raise aminoglycoside levels when absorption occurs.
What to do
No action is needed in typical adult use; monitor renal function in neonates or those with renal impairment or intestinal inflammation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Ibuprofen with Paromomycin?
MediHelp rates the interaction as minor. Ibuprofen and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin is minimally absorbed, so systemic interactions are unlikely in most patients. The reported effect is in preterm infants given ibuprofen, in whom reduced renal clearance increases aminoglycoside levels.
How serious is the interaction between Ibuprofen and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed in typical adult use; monitor renal function in neonates or those with renal impairment or intestinal inflammation.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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