Drug interactions
Ibuprofen + Penicillin g
Severity: Minor
Ibuprofen and Penicillin g: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as ibuprofen can reduce renal tubular secretion of penicillins and may modestly raise penicillin levels. NSAID-related renal impairment can further reduce penicillin clearance. Clinically significant effects are uncommon at usual doses.
What this interaction means in plain words
Ibuprofen and Penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Penicillin g belongs to Anti Bacterial.
Why it happens
Competition for renal tubular anionic secretion and possible reduced renal function from NSAID effect.
What to do
No routine adjustment is needed; monitor renal function and watch for penicillin toxicity such as neurotoxicity if high doses are used in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Penicillin g?
MediHelp rates the interaction as minor. Ibuprofen and Penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs such as ibuprofen can reduce renal tubular secretion of penicillins and may modestly raise penicillin levels. NSAID-related renal impairment can further reduce penicillin clearance. Clinically significant effects are uncommon at usual doses.
How serious is the interaction between Ibuprofen and Penicillin g?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor renal function and watch for penicillin toxicity such as neurotoxicity if high doses are used in renal impairment.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
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