Drug interactions
Ibuprofen + Pretomanid
Severity: Moderate
Ibuprofen and Pretomanid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The pretomanid-containing regimen is associated with hepatotoxicity, and additional agents with hepatotoxic potential may increase the risk of liver injury. Ibuprofen rarely causes liver injury, so the added risk is modest.
What this interaction means in plain words
Ibuprofen and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive hepatotoxic potential; no specific pharmacokinetic mechanism is established.
What to do
Monitor liver function regularly during treatment and use the lowest ibuprofen dose for the shortest time, or choose an alternative analgesic. Stop hepatotoxic drugs if transaminases rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Ibuprofen with Pretomanid?
MediHelp rates the interaction as moderate. Ibuprofen and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The pretomanid-containing regimen is associated with hepatotoxicity, and additional agents with hepatotoxic potential may increase the risk of liver injury. Ibuprofen rarely causes liver injury, so the added risk is modest.
How serious is the interaction between Ibuprofen and Pretomanid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function regularly during treatment and use the lowest ibuprofen dose for the shortest time, or choose an alternative analgesic. Stop hepatotoxic drugs if transaminases rise significantly.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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