Drug interactions
Ibuprofen + Trazodone
Severity: Moderate
Ibuprofen and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has serotonergic activity that can impair platelet function, and together with ibuprofen this raises the risk of bleeding, particularly from the upper gastrointestinal tract. The risk is higher in older adults and with a history of ulcers.
What this interaction means in plain words
Ibuprofen and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive impairment of platelet aggregation, via serotonin reuptake inhibition in platelets and NSAID cyclooxygenase inhibition, plus NSAID gastric mucosal injury.
What to do
Watch for signs of GI bleeding such as black stools or anemia, and consider gastroprotection with a proton pump inhibitor in high-risk patients. Use the lowest effective ibuprofen dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Ibuprofen with Trazodone?
MediHelp rates the interaction as moderate. Ibuprofen and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has serotonergic activity that can impair platelet function, and together with ibuprofen this raises the risk of bleeding, particularly from the upper gastrointestinal tract. The risk is higher in older adults and with a history of ulcers.
How serious is the interaction between Ibuprofen and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of GI bleeding such as black stools or anemia, and consider gastroprotection with a proton pump inhibitor in high-risk patients. Use the lowest effective ibuprofen dose for the shortest time.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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