Drug interactions
Ibuprofen / famotidine + Posaconazole
Severity: Moderate
Ibuprofen / famotidine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine raises gastric pH, which reduces absorption of posaconazole oral suspension and may lower antifungal exposure. Delayed-release tablets and the injection are much less affected. Ibuprofen has no meaningful effect on posaconazole.
What this interaction means in plain words
Ibuprofen / famotidine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Famotidine increases gastric pH, impairing dissolution and absorption of posaconazole suspension.
What to do
Use posaconazole delayed-release tablets or injection instead of suspension. If suspension is necessary, avoid acid suppressants or check posaconazole trough levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Ibuprofen / famotidine with Posaconazole?
MediHelp rates the interaction as moderate. Ibuprofen / famotidine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Famotidine raises gastric pH, which reduces absorption of posaconazole oral suspension and may lower antifungal exposure. Delayed-release tablets and the injection are much less affected. Ibuprofen has no meaningful effect on posaconazole.
How serious is the interaction between Ibuprofen / famotidine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use posaconazole delayed-release tablets or injection instead of suspension. If suspension is necessary, avoid acid suppressants or check posaconazole trough levels.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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