Drug interactions
Ibutilide + Itraconazole
Severity: Major
Ibutilide and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide can cause dose-related QT prolongation and torsades de pointes, and itraconazole adds a further QT-prolonging effect. The combination increases the risk of life-threatening ventricular arrhythmia.
What this interaction means in plain words
Ibutilide and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibutilide belongs to Cardiovascular; Itraconazole belongs to Anti Fungals.
Why it happens
Additive blockade of cardiac repolarization causing QT prolongation.
What to do
Avoid the combination where possible. If ibutilide cardioversion is essential, use continuous ECG monitoring with correction of potassium and magnesium, and consider whether itraconazole can be interrupted or substituted.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Itraconazole?
MediHelp rates the interaction as major. Ibutilide and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibutilide can cause dose-related QT prolongation and torsades de pointes, and itraconazole adds a further QT-prolonging effect. The combination increases the risk of life-threatening ventricular arrhythmia.
How serious is the interaction between Ibutilide and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If ibutilide cardioversion is essential, use continuous ECG monitoring with correction of potassium and magnesium, and consider whether itraconazole can be interrupted or substituted.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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