Drug interactions
Ibutilide + Oxaliplatin
Severity: Major
Ibutilide and Oxaliplatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and ibutilide carries a substantial risk of torsades de pointes on its own. Adding oxaliplatin, which has been associated with QT prolongation and can cause electrolyte disturbances, further increases arrhythmia risk.
What this interaction means in plain words
Ibutilide and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibutilide belongs to Cardiovascular; Oxaliplatin belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QT interval) through pharmacodynamic effects.
What to do
Avoid the combination where possible; if ibutilide is essential, monitor ECG continuously and correct potassium and magnesium beforehand. Consider an alternative antiarrhythmic strategy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Oxaliplatin?
MediHelp rates the interaction as major. Ibutilide and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and ibutilide carries a substantial risk of torsades de pointes on its own. Adding oxaliplatin, which has been associated with QT prolongation and can cause electrolyte disturbances, further increases arrhythmia risk.
How serious is the interaction between Ibutilide and Oxaliplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if ibutilide is essential, monitor ECG continuously and correct potassium and magnesium beforehand. Consider an alternative antiarrhythmic strategy.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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