Drug interactions
Idarubicin + Tucatinib
Severity: Moderate
Idarubicin and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein and may raise exposure to idarubicin, which is a P-gp substrate. Higher anthracycline levels could worsen myelosuppression and cardiotoxicity.
What this interaction means in plain words
Idarubicin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idarubicin belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits P-glycoprotein efflux, reducing idarubicin transport and increasing its systemic exposure.
What to do
Monitor blood counts and cardiac function closely when the two are combined. Consider idarubicin dose reduction if marked toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idarubicin
- Adenovirus types 4 and 7 live + Idarubicin Contraindicated
- Belatacept + Idarubicin Major
- Cyclophosphamide + Idarubicin Major
- Deferiprone + Idarubicin Major
- Dengue vaccine + Idarubicin Major
- Etrasimod + Idarubicin Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Idarubicin with Tucatinib?
MediHelp rates the interaction as moderate. Idarubicin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits P-glycoprotein and may raise exposure to idarubicin, which is a P-gp substrate. Higher anthracycline levels could worsen myelosuppression and cardiotoxicity.
How serious is the interaction between Idarubicin and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function closely when the two are combined. Consider idarubicin dose reduction if marked toxicity develops.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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