Drug interactions
Idecabtagene vicleucel + Vedolizumab
Severity: Moderate
Idecabtagene vicleucel and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idecabtagene vicleucel is a BCMA-directed CAR T-cell therapy given after lymphodepleting chemotherapy and is associated with prolonged cytopenias and infection risk. Adding an integrin antagonist such as vedolizumab could add to infection risk, although its gut-selective action makes the systemic effect smaller than with other immunosuppressants.
What this interaction means in plain words
Idecabtagene vicleucel and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idecabtagene vicleucel belongs to Oncology; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunomodulation: gut-selective integrin blockade combined with profound CAR T-related immune suppression; the interaction is largely theoretical.
What to do
Review the need for vedolizumab around CAR T infusion and consider holding it during lymphodepletion and early recovery. Monitor for infections and cytopenias closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Idecabtagene vicleucel
Frequently asked questions
Can I take Idecabtagene vicleucel with Vedolizumab?
MediHelp rates the interaction as moderate. Idecabtagene vicleucel and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idecabtagene vicleucel is a BCMA-directed CAR T-cell therapy given after lymphodepleting chemotherapy and is associated with prolonged cytopenias and infection risk. Adding an integrin antagonist such as vedolizumab could add to infection risk, although its gut-selective action makes the systemic effect smaller than with other immunosuppressants.
How serious is the interaction between Idecabtagene vicleucel and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the need for vedolizumab around CAR T infusion and consider holding it during lymphodepletion and early recovery. Monitor for infections and cytopenias closely.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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