Drug interactions
Idelalisib + Levonorgestrel
Severity: Moderate
Idelalisib and Levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can raise levonorgestrel exposure, increasing progestogenic adverse effects. Clinical consequences are generally modest.
What this interaction means in plain words
Idelalisib and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Levonorgestrel belongs to Endocrine.
Why it happens
Strong CYP3A inhibition reduces levonorgestrel metabolism.
What to do
Monitor for progestogenic adverse effects such as bleeding changes, headache or mood changes, and reassess the contraceptive choice if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levonorgestrel
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Levonorgestrel?
MediHelp rates the interaction as moderate. Idelalisib and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and can raise levonorgestrel exposure, increasing progestogenic adverse effects. Clinical consequences are generally modest.
How serious is the interaction between Idelalisib and Levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects such as bleeding changes, headache or mood changes, and reassess the contraceptive choice if they occur.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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