Drug interactions
Idelalisib + Nifedipine
Severity: Major
Idelalisib and Nifedipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can substantially increase nifedipine exposure. This raises the risk of marked hypotension, tachycardia and peripheral edema.
What this interaction means in plain words
Idelalisib and Nifedipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idelalisib belongs to Oncology; Nifedipine belongs to Cardiovascular.
Why it happens
Idelalisib strongly inhibits CYP3A-mediated metabolism of nifedipine.
What to do
Use a lower nifedipine dose or an alternative antihypertensive, and monitor blood pressure closely. Reassess the dose when idelalisib is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nifedipine
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Nifedipine?
MediHelp rates the interaction as major. Idelalisib and Nifedipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and can substantially increase nifedipine exposure. This raises the risk of marked hypotension, tachycardia and peripheral edema.
How serious is the interaction between Idelalisib and Nifedipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower nifedipine dose or an alternative antihypertensive, and monitor blood pressure closely. Reassess the dose when idelalisib is stopped.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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