Drug interactions
Idelalisib + Praziquantel
Severity: Moderate
Idelalisib and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and is expected to increase praziquantel exposure. This may increase adverse effects such as dizziness, headache and gastrointestinal upset.
What this interaction means in plain words
Idelalisib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Praziquantel belongs to Anti Parasitic.
Why it happens
Strong CYP3A4 inhibition reduces praziquantel first-pass and systemic metabolism.
What to do
Monitor for praziquantel adverse effects and avoid driving after doses. Consider the lowest effective praziquantel dose within the standard regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Praziquantel?
MediHelp rates the interaction as moderate. Idelalisib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and is expected to increase praziquantel exposure. This may increase adverse effects such as dizziness, headache and gastrointestinal upset.
How serious is the interaction between Idelalisib and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for praziquantel adverse effects and avoid driving after doses. Consider the lowest effective praziquantel dose within the standard regimen.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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