Drug interactions
Idelalisib + Sorafenib
Severity: Moderate
Idelalisib and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and may raise sorafenib concentrations. However, sorafenib is also cleared by UGT1A9 and strong CYP3A4 inhibitors have had limited effect on its exposure.
What this interaction means in plain words
Idelalisib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated sorafenib metabolism by idelalisib.
What to do
Monitor for sorafenib toxicity such as hand-foot skin reaction, hypertension and diarrhea. Reduce or interrupt the sorafenib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Sorafenib?
MediHelp rates the interaction as moderate. Idelalisib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A4 inhibitor and may raise sorafenib concentrations. However, sorafenib is also cleared by UGT1A9 and strong CYP3A4 inhibitors have had limited effect on its exposure.
How serious is the interaction between Idelalisib and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib toxicity such as hand-foot skin reaction, hypertension and diarrhea. Reduce or interrupt the sorafenib dose if adverse effects occur.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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