Drug interactions
Idelalisib + Vinorelbine
Severity: Major
Idelalisib and Vinorelbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can raise vinorelbine concentrations. This may intensify myelosuppression, neurotoxicity and gastrointestinal toxicity, and both drugs can cause neutropenia.
What this interaction means in plain words
Idelalisib and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idelalisib belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Strong CYP3A inhibition by idelalisib decreases hepatic and intestinal metabolism of vinorelbine.
What to do
Avoid concurrent use where an alternative exists. If it is necessary, monitor neutrophil counts frequently and for neuropathy and constipation, and reduce the vinorelbine dose as clinically indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinorelbine
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Vinorelbine?
MediHelp rates the interaction as major. Idelalisib and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and can raise vinorelbine concentrations. This may intensify myelosuppression, neurotoxicity and gastrointestinal toxicity, and both drugs can cause neutropenia.
How serious is the interaction between Idelalisib and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where an alternative exists. If it is necessary, monitor neutrophil counts frequently and for neuropathy and constipation, and reduce the vinorelbine dose as clinically indicated.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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