Drug interactions
Ifosfamide + Lopinavir
Severity: Moderate
Ifosfamide and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, boosted with ritonavir, strongly inhibits CYP3A4 and may reduce ifosfamide activation. This could lessen antitumor effect while altering the profile of neurotoxic metabolites.
What this interaction means in plain words
Ifosfamide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Lopinavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by the lopinavir/ritonavir combination alters ifosfamide metabolism.
What to do
Monitor for reduced response and for neurotoxicity or nephrotoxicity, and consider a non-boosted antiretroviral regimen if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Ifosfamide with Lopinavir?
MediHelp rates the interaction as moderate. Ifosfamide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, boosted with ritonavir, strongly inhibits CYP3A4 and may reduce ifosfamide activation. This could lessen antitumor effect while altering the profile of neurotoxic metabolites.
How serious is the interaction between Ifosfamide and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response and for neurotoxicity or nephrotoxicity, and consider a non-boosted antiretroviral regimen if feasible.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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