Drug interactions
Ifosfamide + Stiripentol
Severity: Moderate
Ifosfamide and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces several CYP enzymes, including CYP3A4 and CYP2C19, which take part in ifosfamide activation and in forming its neurotoxic and nephrotoxic metabolite. Exposure to active and toxic metabolites may therefore change unpredictably, altering efficacy or toxicity.
What this interaction means in plain words
Ifosfamide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4 and CYP2C19, altering ifosfamide metabolic activation and toxic metabolite formation.
What to do
Monitor for ifosfamide neurotoxicity, urotoxicity and myelosuppression, and for loss of efficacy. Adjust the ifosfamide dose according to tolerance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Ifosfamide with Stiripentol?
MediHelp rates the interaction as moderate. Ifosfamide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces several CYP enzymes, including CYP3A4 and CYP2C19, which take part in ifosfamide activation and in forming its neurotoxic and nephrotoxic metabolite. Exposure to active and toxic metabolites may therefore change unpredictably, altering efficacy or toxicity.
How serious is the interaction between Ifosfamide and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ifosfamide neurotoxicity, urotoxicity and myelosuppression, and for loss of efficacy. Adjust the ifosfamide dose according to tolerance.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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