Drug interactions
Ifosfamide + Vedolizumab
Severity: Moderate
Ifosfamide and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide causes myelosuppression and immunosuppression, which may add to the immune effects of vedolizumab. This may increase the risk of infection, though vedolizumab acts mainly in the gut.
What this interaction means in plain words
Ifosfamide and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression: cytotoxic marrow suppression plus gut-selective alpha4beta7 integrin blockade.
What to do
Monitor blood counts and for signs of infection during chemotherapy cycles. Reassess vedolizumab timing if severe neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Vedolizumab?
MediHelp rates the interaction as moderate. Ifosfamide and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide causes myelosuppression and immunosuppression, which may add to the immune effects of vedolizumab. This may increase the risk of infection, though vedolizumab acts mainly in the gut.
How serious is the interaction between Ifosfamide and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of infection during chemotherapy cycles. Reassess vedolizumab timing if severe neutropenia occurs.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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