Drug interactions
Iloperidone + Imatinib
Severity: Moderate
Iloperidone and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs inhibit enzymes involved in each other's metabolism. Imatinib inhibits CYP2D6 and may raise iloperidone levels, which carries a QT-prolonging risk. Iloperidone may modestly raise imatinib levels via CYP3A4.
What this interaction means in plain words
Iloperidone and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP2D6 metabolism of iloperidone, and iloperidone may weakly inhibit CYP3A4 metabolism of imatinib.
What to do
Monitor ECG and QTc, especially with other risk factors, and watch for imatinib adverse effects; reduce iloperidone dose if QT prolongation or excess effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iloperidone and Imatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Imatinib?
MediHelp rates the interaction as moderate. Iloperidone and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs inhibit enzymes involved in each other's metabolism. Imatinib inhibits CYP2D6 and may raise iloperidone levels, which carries a QT-prolonging risk. Iloperidone may modestly raise imatinib levels via CYP3A4.
How serious is the interaction between Iloperidone and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and QTc, especially with other risk factors, and watch for imatinib adverse effects; reduce iloperidone dose if QT prolongation or excess effects occur.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
