Drug interactions
Iloperidone + Ipratropium-salbutamol
Severity: Moderate
Iloperidone and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QT interval, and salbutamol can add to this through hypokalemia and direct cardiac effects. Iloperidone also has some anticholinergic activity that is additive to ipratropium, although this is usually minor.
What this interaction means in plain words
Iloperidone and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta-agonist-induced hypokalemia, plus minor additive antimuscarinic effects.
What to do
Monitor ECG and serum potassium in patients with other QT risk factors or high-dose salbutamol use. Avoid excessive beta-agonist dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Iloperidone and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone prolongs the QT interval, and salbutamol can add to this through hypokalemia and direct cardiac effects. Iloperidone also has some anticholinergic activity that is additive to ipratropium, although this is usually minor.
How serious is the interaction between Iloperidone and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium in patients with other QT risk factors or high-dose salbutamol use. Avoid excessive beta-agonist dosing.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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