Drug interactions
Iloperidone + Loxapine
Severity: Major
Iloperidone and Loxapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two antipsychotics together increases dopamine blockade and the risk of extrapyramidal symptoms, neuroleptic malignant syndrome, sedation and orthostatic hypotension. Iloperidone also prolongs the QT interval, which adds to arrhythmia risk.
What this interaction means in plain words
Iloperidone and Loxapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Iloperidone belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Additive dopamine D2 antagonism, sedation and alpha-adrenergic blockade, with additive QT prolongation potential.
What to do
Avoid antipsychotic polypharmacy where possible. If combined, monitor ECG and electrolytes, movement symptoms, blood pressure and body temperature.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iloperidone and Loxapine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Loxapine?
MediHelp rates the interaction as major. Iloperidone and Loxapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two antipsychotics together increases dopamine blockade and the risk of extrapyramidal symptoms, neuroleptic malignant syndrome, sedation and orthostatic hypotension. Iloperidone also prolongs the QT interval, which adds to arrhythmia risk.
How serious is the interaction between Iloperidone and Loxapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy where possible. If combined, monitor ECG and electrolytes, movement symptoms, blood pressure and body temperature.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
