Drug interactions
Iloperidone + Maprotiline
Severity: Major
Iloperidone and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and iloperidone carries a recognised QT liability. Combined use raises the risk of ventricular arrhythmias including torsades de pointes, and additive sedation and orthostatic hypotension may also occur.
What this interaction means in plain words
Iloperidone and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Iloperidone belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac potassium channel effects, plus additive CNS depression and alpha-adrenergic blockade.
What to do
Avoid the combination where possible, particularly with other risk factors such as hypokalemia or bradycardia. If used, obtain a baseline ECG, correct electrolytes and monitor QTc and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Maprotiline?
MediHelp rates the interaction as major. Iloperidone and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and iloperidone carries a recognised QT liability. Combined use raises the risk of ventricular arrhythmias including torsades de pointes, and additive sedation and orthostatic hypotension may also occur.
How serious is the interaction between Iloperidone and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly with other risk factors such as hypokalemia or bradycardia. If used, obtain a baseline ECG, correct electrolytes and monitor QTc and sedation.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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