Drug interactions
Iloperidone + Methocarbamol
Severity: Moderate
Iloperidone and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an atypical antipsychotic that can cause somnolence, dizziness and orthostatic hypotension. With methocarbamol, sedation and the risk of falls may increase.
What this interaction means in plain words
Iloperidone and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from antipsychotic receptor blockade and methocarbamol's central sedative effect.
What to do
Monitor for sedation and orthostatic symptoms, especially during dose titration. Counsel patients about driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Methocarbamol?
MediHelp rates the interaction as moderate. Iloperidone and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is an atypical antipsychotic that can cause somnolence, dizziness and orthostatic hypotension. With methocarbamol, sedation and the risk of falls may increase.
How serious is the interaction between Iloperidone and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic symptoms, especially during dose titration. Counsel patients about driving and fall risk.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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