Drug interactions
Iloperidone + Naratriptan
Severity: Minor
Iloperidone and Naratriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an atypical antipsychotic with strong 5-HT2A antagonism. Triptans have rarely been linked to serotonin syndrome, and antipsychotics can rarely cause neuroleptic malignant syndrome. Together the theoretical risk is low.
What this interaction means in plain words
Iloperidone and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic and dopaminergic effects; the mechanism is not well established.
What to do
Monitor for fever, rigidity, clonus and altered mental status when starting or increasing doses. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Naratriptan?
MediHelp rates the interaction as minor. Iloperidone and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is an atypical antipsychotic with strong 5-HT2A antagonism. Triptans have rarely been linked to serotonin syndrome, and antipsychotics can rarely cause neuroleptic malignant syndrome. Together the theoretical risk is low.
How serious is the interaction between Iloperidone and Naratriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fever, rigidity, clonus and altered mental status when starting or increasing doses. No routine dose change is needed.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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