Drug interactions
Iloperidone + Nicardipine
Severity: Moderate
Iloperidone and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has been described as a weak time-dependent CYP3A inhibitor, so it may modestly raise nicardipine concentrations. This could increase hypotension, dizziness and reflex tachycardia. Both drugs can also lower blood pressure through additive effects, since iloperidone causes orthostatic hypotension via alpha-1 blockade.
What this interaction means in plain words
Iloperidone and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Iloperidone may inhibit CYP3A4 and adds alpha-1 adrenergic blockade to the vasodilation of nicardipine.
What to do
Monitor blood pressure, including orthostatic readings, when starting or adjusting either drug. Reduce the nicardipine dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Nicardipine?
MediHelp rates the interaction as moderate. Iloperidone and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has been described as a weak time-dependent CYP3A inhibitor, so it may modestly raise nicardipine concentrations. This could increase hypotension, dizziness and reflex tachycardia. Both drugs can also lower blood pressure through additive effects, since iloperidone causes orthostatic hypotension via alpha-1 blockade.
How serious is the interaction between Iloperidone and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including orthostatic readings, when starting or adjusting either drug. Reduce the nicardipine dose if symptomatic hypotension develops.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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