Drug interactions
Iloperidone + Nimodipine
Severity: Moderate
Iloperidone and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has weak time-dependent CYP3A inhibition and may modestly raise nimodipine levels. Both drugs can lower blood pressure, so additive hypotension and orthostasis are possible.
What this interaction means in plain words
Iloperidone and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Nimodipine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by iloperidone plus additive hypotensive effects from alpha-1 blockade.
What to do
Monitor blood pressure and orthostatic symptoms. Reduce the nimodipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Nimodipine?
MediHelp rates the interaction as moderate. Iloperidone and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has weak time-dependent CYP3A inhibition and may modestly raise nimodipine levels. Both drugs can lower blood pressure, so additive hypotension and orthostasis are possible.
How serious is the interaction between Iloperidone and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms. Reduce the nimodipine dose if hypotension occurs.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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