Drug interactions
Iloperidone + Orphenadrin
Severity: Moderate
Iloperidone and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is sedating and can cause orthostatic hypotension, and orphenadrine adds sedative and anticholinergic effects. The combination may increase drowsiness, dizziness and cognitive impairment.
What this interaction means in plain words
Iloperidone and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression and anticholinergic effects.
What to do
Monitor for sedation, orthostatic hypotension and anticholinergic symptoms, and counsel against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Orphenadrin?
MediHelp rates the interaction as moderate. Iloperidone and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is sedating and can cause orthostatic hypotension, and orphenadrine adds sedative and anticholinergic effects. The combination may increase drowsiness, dizziness and cognitive impairment.
How serious is the interaction between Iloperidone and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and anticholinergic symptoms, and counsel against driving until the response is known.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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