Drug interactions
Iloperidone + Oxymorphone
Severity: Moderate
Iloperidone and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, so combining them can increase drowsiness, dizziness and orthostatic hypotension. Opioid-related respiratory depression may be additive in susceptible patients.
What this interaction means in plain words
Iloperidone and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant and hypotensive effects from opioid agonism and antipsychotic receptor antagonism (histamine, alpha-adrenergic).
What to do
Start with lower doses of the opioid and monitor sedation and blood pressure, particularly on initiation or dose increases. Counsel patients about driving and rising slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Oxymorphone?
MediHelp rates the interaction as moderate. Iloperidone and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, so combining them can increase drowsiness, dizziness and orthostatic hypotension. Opioid-related respiratory depression may be additive in susceptible patients.
How serious is the interaction between Iloperidone and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower doses of the opioid and monitor sedation and blood pressure, particularly on initiation or dose increases. Counsel patients about driving and rising slowly.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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