Drug interactions
Iloperidone + Procarbazine
Severity: Moderate
Iloperidone and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has monoamine oxidase inhibiting activity and may add to the serotonergic and dopamine-modulating effects of antipsychotics. This could raise the risk of serotonin toxicity or neuroleptic malignant syndrome, and additive sedation and hypotension may also occur. The clinical evidence is limited and mostly theoretical.
What this interaction means in plain words
Iloperidone and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Weak MAO inhibition by procarbazine combined with antipsychotic receptor antagonism may produce additive serotonergic and dopaminergic effects.
What to do
Monitor for mental status changes, hyperthermia, rigidity, clonus and autonomic instability, particularly after starting or increasing doses. Stop both agents and give supportive care if serotonin syndrome or neuroleptic malignant syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Procarbazine?
MediHelp rates the interaction as moderate. Iloperidone and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has monoamine oxidase inhibiting activity and may add to the serotonergic and dopamine-modulating effects of antipsychotics. This could raise the risk of serotonin toxicity or neuroleptic malignant syndrome, and additive sedation and hypotension may also occur. The clinical evidence is limited and mostly theoretical.
How serious is the interaction between Iloperidone and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status changes, hyperthermia, rigidity, clonus and autonomic instability, particularly after starting or increasing doses. Stop both agents and give supportive care if serotonin syndrome or neuroleptic malignant syndrome is suspected.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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