Drug interactions
Iloperidone + Propafenone
Severity: Major
Iloperidone and Propafenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits CYP2D6 and can raise iloperidone concentrations, and both drugs affect QT. This increases the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Iloperidone and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Iloperidone belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
CYP2D6 inhibition by propafenone reduces iloperidone clearance, plus additive QT prolongation.
What to do
Reduce the iloperidone dose per labeling with strong CYP2D6 inhibitors and monitor ECG and electrolytes. Consider an alternative antipsychotic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Propafenone?
MediHelp rates the interaction as major. Iloperidone and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propafenone inhibits CYP2D6 and can raise iloperidone concentrations, and both drugs affect QT. This increases the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Iloperidone and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the iloperidone dose per labeling with strong CYP2D6 inhibitors and monitor ECG and electrolytes. Consider an alternative antipsychotic.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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