Drug interactions
Iloperidone + Quetiapine
Severity: Major
Iloperidone and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two atypical antipsychotics adds to QT prolongation, sedation, orthostatic hypotension and extrapyramidal or neuroleptic malignant syndrome risk. Iloperidone is itself associated with QT prolongation.
What this interaction means in plain words
Iloperidone and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Iloperidone belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive dopamine and multi-receptor antagonism and additive effects on cardiac repolarization.
What to do
Avoid antipsychotic polypharmacy where possible. If used together, monitor ECG, electrolytes, blood pressure and movement disorders.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Quetiapine?
MediHelp rates the interaction as major. Iloperidone and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two atypical antipsychotics adds to QT prolongation, sedation, orthostatic hypotension and extrapyramidal or neuroleptic malignant syndrome risk. Iloperidone is itself associated with QT prolongation.
How serious is the interaction between Iloperidone and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy where possible. If used together, monitor ECG, electrolytes, blood pressure and movement disorders.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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